Here is a bit of an article entitled~ *Lipids in polycystic ovary syndrome: Role of hyperinsulinemia and effects of metformin* Just FYI, I have PCOS & I will be starting this med as soon as I can get my labs back. YEAH!!!!
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathes, affecting approximately 4% to 7% of women of reproductive age.1-3 PCOS is associated with a broad range of clinical presentations including hirsutism, menstrual irregularities, and infertility. Most women with PCOS have hyperandrogenemia, elevated luteinizing hormone (LH), and normal or decreased follicle-stimulating hormone (FSH).
Metabolic abnormalities and sequelae of PCOS resemble those of syndrome X. PCOS is characterized by insulin resistance and compensatory hyperinsulinemia. As in syndrome X, women with PCOS are often obese, usually because of excessive central fat accumulation. Dyslipidemia in PCOS is prevalent and characterized by elevated plasma levels of cholesterol, low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), and triglycerides, with concomitantly reduced concentration of high-density lipoproteins (HDL). Fibrinolytic function in PCOS is abnormal because of higher fibrinogen and increased plasminogen activator inhibitor-1 (PAI-I). Women with a history of PCOS have increased systolic blood pressure and increased thickness of arterial intima-media. Long-term complications of PCOS include increased risk of type 2 diabetes mellitus, atherosclerosis, coronary artery disease, and myocardial infarction.
New insights into the relationship between insulin resistance, compensatory hyperinsulinemia, and development of PCOS led to the use of insulinomimetic/insulin sensitizing agents. The most popular of these agents is metformin, a biguanide used extensively in type 2 diabetes. Metformin actions include inhibition of hepatic glucose production and an increase in peripheral insulin sensitivity. Use of metformin in diabetics has been shown to decrease risks of cardiovascular complications. Metformin use in PCOS led to an increase in insulin sensitivity accompanied by decreased insulin and androgen levels and frequently resulted in restoration of menstrual function. The best response to metformin (defined as restoration of menstrual cycle) was observed in hyperinsulinemic and obese women.
Subscribe to:
Post Comments (Atom)
Bzzzzzzz!
Winzy Wins!
Click it
Original Design by Jennifer *SIS*
Large range of products, styles & colors
The Face of Cute
Sweet Ellybelly
2 comments:
Wow! I laughed some, I cried some, I wet myself just a little bit. All-in-all, very informative and interesting article!
Thank you for posting this article for the education of others. I know that you must be a very well-educated person to read about all this stuff and understand it. As for me though I am not too bright. And I hate to use any sort of punctuation other than the period (.). Thank you again for your very nice blog and for everything that you have ever done for anyone and I like to read about your dog more and forwarded emails less.
Post a Comment